Fibrinogen: A Circulating Factor in Search for Its Genetic Architecture

Fibrinogen: a circulating factor in search of its genetic architecture.

Fibrinogen gene regulation.

The Aα, Bβ and γ polypeptide chains of fibrinogen are encoded by a three gene cluster on human chromosome four. The fibrinogen genes (FGB-FGA-FGG) are expressed almost exclusively in hepatocytes where their output is coordinated to ensure a sufficient mRNA pool for each chain and maintain an abundant plasma fibrinogen protein level. Fibrinogen gene expression is controlled by the activity of pr...

Integrated Process Planning and Active Scheduling in a Supply Chain-A Learnable Architecture Approach

Through the lens of supply chain management, integrating process planning decisions and scheduling plans becomes an issue of great challenge and importance. Dealing with the problem paves the way to devising operation schedules with minimum makespan; considering the flexible process sequences, it can be viewed as a fundamental tool for achieving the scheme, too. To deal with this integration, t...

A genome search for genetic determinants that influence plasma fibrinogen levels.

BACKGROUND Fibrinogen levels are a widely accepted risk factor for cardiovascular disease, but the extent of the genetic component is unknown. MATERIALS AND RESULTS To search for these genes, we conducted a genome-wide scan using 21 Spanish families from the Genetic Analysis of Idiopathic Thrombophila (GAIT) Project. Two loci were detected: 1 on chromosome 12 and another on chromosome 14. The...

Association of Hepatocyte Growth Factor Genetic Variation (S3735520) and Its Concentration in Autism Spectrum Disorders: A Case-control Study

Background: Hepatocyte Growth Factor (HGF) was shown to play a key role in synaptogenesis, survival, maturation, and reconstruction of neuron cells and was shown to be implicated in Autism Spectrum Disorder (ASD). Objectives: Assessing the relationship between HGF (rs3735520) gene polymorphism and its circulating levels in ASD. Materials & Methods: A total of 140 ASD patients and 120 children...